How much is the loader configuration

  • (PDF) Structure of the cohesin loader Scc2

    Jan 06, 2017 · The same colouring scheme is used in the corresponding crystal structures of Scc2 and Scc4 as shown in (b,d). structure of the cohesin loader Scc2 and insight into cohesinopathy. Proc. Natl.

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  • Crystal structure of the cohesin loader Scc2 and insight

    Nov 01, 2016 · In this study, we report the crystal structure of a fungal Scc2 protein, which represents a high-resolution snapshot of the cohesin loader. We have identified a set of Scc2 mutations in cohesinopathy that disrupt the binding of Scc2 to the kleisin subunit of cohesin. Our results provide critical insight into cohesin loading and cohesinopathy.

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  • Condensin complexes: understanding loop extrusion one

    The crystal structure of the S. cerevisiae condensin HAWK, Ycg1 and Kleisin, Brn1 in complex with DNA suggest that Brn1 folds over and interact with DNA via a patch of conserved positively charged residues . Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy.

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  • Structural insights into DNA loop extrusion by SMC protein

    Dec 01, 2020 · Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy Proc Natl Acad Sci U S A, 113 ( 2016 ), pp. 12444 - 12449 CrossRef View Record in Scopus Google Scholar

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  • ‪Dominika Borek‬ - ‪Google Scholar‬

    Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy S Kikuchi, DM Borek, Z Otwinowski, DR Tomchick, H Yu Proceedings of the National Academy of …

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  • Structural Insights into Ring Formation of Cohesin and

    Cohesin complexes are dynamic as a result of two opposing activities: a DNA-loading activity mediated by the Scc2-Scc4 complex and a releasing activity elicited by the Pds5-Wapl-Scc3 complex. Crystal structures of these proteins are providing insight into their function.

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  • Crystal structure of the cohesin loader Scc2 and insight

    Oct 18, 2016 · The U.S. Department of Energy's Office of Scientific and Technical Information

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  • Mutation Spectrum and Genotype–Phenotype Correlation in

    Ireneusz Litwin, Robert Wysocki, New insights into cohesin loading, Current Genetics, 10.1007/s00294-017-0723-6, 64, 1, Diana R. Tomchick, Hongtao Yu, Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy, Proceedings of the National Academy of Sciences, 10.1073/pnas.1611333113, 113, 44, (12444-12449), (2016).

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  • New insights into cohesin loading | SpringerLink

     · Jun 19, 2017 · Here we summarize recent developments in the structure of Scc2–Scc4 complex, cohesin loading process, and mediators that determine the Scc2–Scc4 binding patterns to chromatin. Cohesin is a conserved, ring-shaped protein complex that encircles sister chromatids and ensures correct chromosome segregation during mitosis and meiosis.

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  • Identification of Functional Domains in the Cohesin Loader

    Aug 01, 2016 · Cohesin is a multi-subunit complex that plays an essential role in genome stability. Initial association of cohesin with chromosomes requires the loader—a heterodimer composed of [Scc4][1] and [Scc2][2]. However, very little is known about the loader's mechanism of action. In this study, we performed a genetic screen to identify functional domains in the [Scc4][1] subunit of the loader.

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  • Cohesin codes – interpreting chromatin architecture and

    controversial, but crystal structure analyses of highly conserved SMC complexes provide new insights into this important topic (Box 1). There is also clear evidence that cohesin subsets exhibit different and distinct chromatin-associated dwell times, supporting the notion that cohesin structures cycle between

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  • Structure of the cohesin loader Scc2 - Europe PMC Article

    The cohesin complex (Smc1, Smc3, Scc1 and Scc3) safeguards genome integrity by ensuring correct sister-chromatid segregation during mitosis and meiosis 1,2,3.The topological entrapment of chromosomes by cohesin is catalysed by the cohesin–loader complex Scc2–Scc4 (refs 4, 5).In yeast, Scc2–Scc4 coordinates with the remodels structure of chromatin (RSC) chromatin-remodelling …

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  • Cryo-EM structure of the human cohesin-NIPBL-DNA complex

    Here, we report the cryo–electron microscopy (cryo-EM) structure of human cohesin bound to the C-terminal HEAT repeat domain of NIPBL (NIPBL C; residues 1163 to 2804) and DNA.This structure, together with crystal structures of the human SMC1-SMC3 hinge domains, reveals how cohesin-NIPBL embraces DNA and establishes the basis for NIPBL-DNA–dependent activation of cohesin's ATPase …

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  • Structure of the cohesin loader Scc2 | Nature …

    Jan 06, 2017 · The crystal structure of Scc2 hook bears good resemblance to the D. M., Otwinowski, Z., Tomchick, D. R. & Yu, H. Crystal structure of the cohesin …

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  • IJMS | Free Full-Text | Functional Coupling between DNA

    Cohesin cycle in human cells. The cohesin loader, Scc2-Scc4, and unloader, Pds5-Wapl, promote dynamic association of cohesin to chromatin in telophase and G1. During S phase, Smc3 acetylation and Sororin binding stabilize cohesin association to chromatin.

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  • NIPBL - Wikipedia

    71175 Ensembl ENSG00000164190 ENSMUSG00000022141 UniProt Q6KC79 Q6KCD5 RefSeq (mRNK) NM_015384 NM_133433 NM_027707 NM_201232 RefSeq (bjelančevina) NP_056199 NP_597677 NP_081983 NP_957684 Lokacija (UCSC) Chr 5: 36.88 – 37.07 Mb Chr 15: 8.29 – 8.44 Mb PubMed pretraga Wikipodaci Pogledaj/uredi – čovjek Pogledaj/uredi – miš Bradavicoliki protein-B (NIPBL), znan …

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  • Crystal structure of the cohesin loader Scc2 and …

    To gain more insight into Scc2 function, we have determined the crystal structure of Scc2 from the thermophilic fungus, Chaetomium thermophilum (Ct). Scc2 consists almost entirely of helical repeats that fold into a molecular hook. The overall structure of Scc2 is similar to two other Scc1-binding HEAT repeat proteins, Scc3 and

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